TITLE: Small Molecule Activators of the TRK Receptors for Neuroprotection PRINCIPAL INVESTIGATOR: Nicholas J. Webster, Ph.D. Small Molecule Activators of the TRK Receptors for Neuroprotection CONTRACTING ORGANIZATION: Veterans Medical Research Foundation

XWH - 08 - 2 - 0067 TITLE : Small Molecule Activators of the Trk Receptors for Neuroprotection PRINCIPAL

XWH - 08 - 2 - 0067 TITLE : Small Molecule Activators of the Trk Receptors for

TITLE: “Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome” PRINCIPAL INVESTIGATOR:

Award Number: W81XWH-10-2-0169 TITLE: “Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome” PRINCIPAL INVESTIGATOR: Lisa Delano-Wood, Ph.D. CONTRACTING ORGANIZATION: Veterans Medical Research Foundation San Diego, CA 92161 REPORT DATE: October 2015 TYPE OF REPORT: Annual Report PREPARED FOR: U.S. Army Medical Research an...

Activation of Trk neurotrophin receptors in the absence of neurotrophins.

Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor autophosphorylation and downstream phosphorylation cascades. Here, we describe an approach to use small molecule agonists to transactivate Trk neurotrophin receptors. Activation of TrkA receptors in PC12 cells an...

Deprenyl changes the expression of Trk-B and P75 NTR receptors in rat after sciatic nerve axotomy

During development many of neurons die by the phenomenon named programmed cell death or apoptosis and this reaction is regulated by neurotrophin (BDNF, NGF, NT3 and NT4/5). These neurotrophins bind to two different classes of transmembrane receptor proteins, the Trks and P75 NTR. Axotomy can induce apoptosis after birth and deprenyl is a an inhibitor of monoamineoxidase type-B and seems to act ...